Journal: bioRxiv
Article Title: Context-bridged associative learning: linking neutral tone engram to fear through shared context
doi: 10.64898/2026.02.26.708189
Figure Lengend Snippet: Longer context exploration during conditioning enables tone fear and reveals latent inhibition after tone preexposure. (A) Experimental design. (B) Freezing during conditioning in Context A; @ p < 0.0001 for all groups compared to “A+Tone; A+Tone”, Tukey’s post hoc test. (C) Freezing in Context B during baseline exploration and during the tone presentation (tone test); * - p < 0.0003 compared to “A+Tone; A+Tone”; + - p < 0.0001 compared to “A+Tone; A+Shock”; ^ - p < 0.0001 compared to “A; A+Tone+Shock”; # - p < 0.0001 compared to freezing in Context A’ within the same group, Tukey’s post hoc test. (D) Freezing during the Context A test; * - p < 0.05, Dunnett’s T3 post hoc test.
Article Snippet: Fear conditioning and memory tests were conducted using the Video Fear Conditioning System (MED Associates Inc., Fairfax, VT, USA) controlled by VideoFreeze software (v2.5.5.0; MED Associates).
Techniques: Inhibition